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Which compounds are suitable for analysis by gas chromatography?

:2024-07-19 16:39:50:

Gas Chromatography (GC) is a widely used technique in the field of chemical analysis, particularly suitable for the analysis of organic compounds. The following are some types of compounds suitable for analysis by gas chromatography and their characteristics:

1. Volatile organic compounds:

Gas chromatography is mainly based on the different distribution coefficients of substances between the mobile phase and the stationary phase to achieve substance separation, so volatile organic compounds are easier to analyze in gas chromatography.

For example, petrochemical products, volatile organic compounds (VOCs) in environmental monitoring, and flavors and additives in food.

2. Compounds of different polarities:

There are various types of stationary phases used in gas chromatography, including weakly polar, non-polar, and polar stationary phases, which enable gas chromatography to analyze various compounds from non-polar to polar.

For example, using weakly polar stationary phases (such as Porapak P, Q, Chromosorb 101, 106, etc.) can analyze non-polar or weakly polar compounds, while using polar stationary phases (such as Porapak R, S, Chromosorb 104, 107, etc.) can analyze polar compounds.

3. Multi component mixture:

Gas chromatography can effectively separate multi-component mixtures by varying the elution time of different components in the chromatographic column.

For example, in environmental monitoring, gas chromatography can be used to analyze various organic pollutants in complex atmospheric, water, and soil samples.

4. Compounds with sensitivity requirements:

The gas chromatograph is equipped with different types of detectors, such as flame photometric detector (FID), electron capture detector (ECD), and nitrogen phosphorus detector (NPD), which have different sensitivities and selectivity for different types of organic compounds.

Therefore, gas chromatography is suitable for compounds that require high-sensitivity analysis, such as drug metabolites in medicine, compounds in biological systems, and pesticide residues in food.

5. Stable compounds at high temperatures:

Due to the high temperature required in gas chromatography analysis, it is suitable for compounds that are stable at high temperatures.

For example, porous polymer fillers (such as Chromosorb, Porapak, and Hayesep series products) are commonly used for the analysis of gases, water, amines, ammonia, low-fat hydrocarbons, solvents, and other substances, with usage temperatures typically ranging from 190 to 350 ℃.

6. Other features:

Gas chromatography analysis has the characteristics of high efficiency, strong selectivity, fast analysis speed, wide application, and easy operation.

For non-volatile liquids and solids, analysis can be carried out through high-temperature cracking and gasification.

In summary, gas chromatography is suitable for analyzing volatile organic compounds, compounds of different polarities, multi-component mixtures, compounds that require sensitivity, and compounds that are stable at high temperatures. By selecting the appropriate mobile phase, stationary phase, and detector, separation and quantitative analysis of different types of organic compounds can be achieved.

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